In my experience as long as they're good quality and regularly checked the little inline filters are OK. I've had one poor quality ebay one drop in half on me, I think the fuel dissolved the glue holding the thing together

I also read somewhere of one causing running issues. When the car was initially started it would run fine for 5 mins and then cut out. It turned out that the filter was fine initially but once fuel started flowing the paper element would swell restricting the flow of fuel.